منابع مشابه
CFTR: New Members Join the Fold
The folding, misfolding, and degradation of membrane proteins is controlled by multiple processes within the cell. In this issue of Cell, Wang et al. (2006) present an interactome for CFTR, the chloride channel that is misfolded and prematurely degraded in cystic fibrosis. Among the proteins interacting with CFTR is a new member of the Hsp90 chaperone system, Aha1, that plays a central role in ...
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Cyclophilins have prolyl isomerase activity, but evidence for their suggested role in protein folding in cells has been scarce; now they have been found to accelerate the folding of mitochondrial precursor proteins.
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S ince Anfinsen (1) first showed that an amino acid sequence defines a structure, physical biochemists have been trying to decode the structural message in the sequence. To accomplish this goal, proteins have been unfolded and refolded under myriad conditions, with increasingly sophisticated folding probes, and at ever finer temporal resolution. However, this work has been largely confined to w...
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Membrane proteins are essential to many cellular processes. However, the systematic study of membrane protein structure has been hindered by the difficulty in obtaining large quantities of these proteins. Protein overexpression using Escherichia coli is commonly used to produce large quantities of protein, but usually yields very little membrane protein. Furthermore, optimization of the express...
متن کاملCaging helps proteins fold.
H ow do proteins fold spontaneously? The quest to answer this question has led to significant developments on theoretical, experimental, and computational fronts in the last decade (1–7). A combination of approaches has provided a detailed understanding of the nature of pathways and the transition states that the polypeptide chain encounters as it traverses the rugged energy landscape. Even as ...
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ژورنال
عنوان ژورنال: Trends in Biochemical Sciences
سال: 2019
ISSN: 0968-0004
DOI: 10.1016/j.tibs.2018.09.013